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From  Tlistmaster Mar  2 09:15:14 2023
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From: "Pau Navarro" <>
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To: Members of AnGenMap <>
Date: Thu, 02 Mar 2023 09:15:14 -0600

Dear colleagues (apologies for cross-posting),

On 31/03/2023, we will host colleagues from various institutions to showcase
pioneering epigenomics research in livestock, illustrating potential research
and applications relevant to livestock biology and production.

The short link to the registration page with details for this event is:

This is also an opportunity to submit posters showcasing your own epigenomic
research, and we hope that we can use the day to initiate and continue plenty
of interesting discussions and collaborations.

We hope you will be able to attend, either in person or online.

The workshop is free, but we ask you to register to attend. Further details
are shown below.
If you have any queries, please contact us at

Please, distribute within your networks if you feel that is appropriate.

Kind regards,
Pau Navarro, James Prendergast and Albert Tenesa (University of Edinburgh),

Livestock Epigenomics Workshop
Hybrid livestock epigenomics workshop hosted at Roslin Institute, showcasing
current research in livestock and selected human studies.

The meeting will take place on Friday 31 March 2023, 09:00 – 15:30 BST. It
will be hybrid and free to attend both in person and online.

The short link to the registration page for this event is:

Registration will be open until the 30/03/2023 at 5 pm UK time, but if you
are registering to attend in person, it would help us to plan refreshments if
you would register before the 19/03/2023 at 5 pm UK time.


TIME: 9.30-10.00
SPEAKER: Helene Kiefer (INRAE)
TITLE: Is the bull a good model to investigate the impact of the sperm
epigenome on fertility and on offspring’s phenotype?

TIME: 10.00-10.30
SPEAKER: Yanni Zeng (Sun-Yat Sen University)
TITLE: Phenome-wide analyses identify the association between the
parent-of-origin effects dependent methylome and the rate of aging in humans

TIME: 10.30-11.00
SPEAKER: Eveline Ibeaga-Awemu (Agriculture and Agri-Food Canada)
TITLE: Potential application of a scalable and affordable DNA methylation
array in the Canadian Dairy Industry

TIME: 11.30-12.00
SPEAKER: Peter J Hansen (University of Florida)
TITLE: Developmental programming during the preimplantation period by choline
in cattle

TIME: 12.00-12.30
SPEAKER: Konrad Rawlik (University of Edinburgh)
TITLE: Utility of admixture for the study of genetic effects on methylation

TIME: 12.30-1.00
SPEAKER: Jessica Powell (University of Edinburgh)
TITLE: Profiling the Immune Epigenome across Global Cattle Breeds


Genomic technologies have empowered and accelerated genetic research and its
impact in breeding. It is, however, clear that genetics only explains a
proportion of the observed variation in health and production traits in
livestock populations. The environment plays an important part in determining
performance, and so do the interactions of the genetic background with known
and unknown environmental factors.

DNA methylation, an epigenetic mark, can be used as proxy of environmental
factors, and to quantify environmental and genome by environment
interactions. This is important because understanding variation improves
estimation of breeding values across environments, through the signature that
these leave in DNA methylation data. Additionally, DNA methylation data holds
promise as a disease biomarker, potentially replacing more invasive or costly

We are thrilled to host this workshop where our colleagues will present some
of their exciting epigenetic research in large ruminants and humans,
including in admixed populations, in a series of morning talks. In the
afternoon, we will have an opportunity to hold informal discussions around

Poster submissions

If you have related work you would like to present at the workshop in poster
format, you will be able to submit your poster during the registration
process. You might need to login to a google account to fill in the poster
submission form. If you join us in person, you are welcome to bring a hard
copy of the poster to display on the day.


We are grateful to our speakers for making this workshop possible. This is a
bit of information about their backgrounds and interests.

Helene Kiefer obtained a permanent researcher position in 2010 at INRAE of
Jouy-en-Josas (near Paris). She developed several tools to study DNA
methylation at a genome-wide scale in cattle: a Roche-NimbleGen custom
microarray, an automated version of RRBS, and she is now involved in the
development of the first Illumina cattle medium density array (RUMIGEN
EpiChip). Her research interest is DNA methylation in cattle with a focus on
bull sperm. She is leading a joint INRAE-ELIANCE team together with a
colleague from ELIANCE.

Yanni Zeng Dr. Zeng studied psychiatric genetics in her PhD in 2013-2016,
supervised by Prof. Andrew McIntosh and Prof. Chris Haley at the University
of Edinburgh. In 2017-2018, she worked in Prof. Chris Haley’s group as a
postdoc exploring the determination of DNA methylation and its impact on
complex traits. In 2018, she joined the Zhongshan School of Medicine at
Sun-Yat Sen University. Her current research interest focuses in genetic,
epigenetic and environmental determination of complex traits.

Eveline Ibeaga-Awemu Dr. Eveline Ibeagha-Awemu is a Senior Research Scientist
with Agriculture and Agri-Food Canada. She has established a national and
international reputation for her research in animal functional genomics and
epigenomics for livestock health management and production. Her research
focuses on applying OMICs and emerging technologies to characterise
regulatory elements in livestock genomes and their contributions to
phenotypic variation in livestock health, production and environmental
adaptation. She has contributed to numerous expert consultancy
meetings/panels and professional societies including holding executive
position as President of the Canadian Society of Animal Science. She has
contributed significantly to scientific innovation through
authorship/co-authorship of over 220 scientific communications, numerous
invited presentations and won many awards including the 2021 CSAS Award for
Technical Innovation in Enhancing the Production of Safe and Affordable Food.

Peter J Hansen is Distinguished Professor at the Dept of Animal Sciences
University of Florida. His research focuses on the biology of early pregnancy
and development of methods to improve fertility and assisted reproductive
technologies in cattle. Particular emphasis is placed on elucidating pathways
by which the mother regulates preimplantation development, minimizing effects
of elevated temperature on fertility and identifying genes controlling
embryonic survival and thermotolerance. He received the B.S. in Agricultural
Sciences from the University of Illinois in 1978 and the M.S. and Ph.D.
degrees from the University of Wisconsin in 1980 and 1983. He did a
postdoctoral fellowship at the University of Florida from 1983-1984 before
joining the faculty at Florida as an assistant professor in 1984. He is
currently President of the Society for the Study of Reproduction.

Konrad Rawlik studied Mathematics and Artificial Intelligence at the
University of Edinburgh, before obtaining an MSc by Research in developmental
neuroscience and a PhD in machine learning. He then joined the Roslin
Institute as a Core Scientist working on complex trait genetics in human.
During this time he worked on the development of novel analytical approaches
for methylation data, development of big-data genetic analyses, and the host
genetics of critical illness in Covid19. He has recently been awarded a
Chancellor’s Fellowship at the Baillie Gifford Pandemic Science Hub (Centre
for Inflammation) at the University of Edinburgh where he will working on
computational biomedical genetics in human.

Jessica Powell will be starting a postdoc position in March at The Roslin
Institute, where she also completed her PhD in cattle epigenetics in 2021.
After her PhD she did a postdoc at The University of Cambridge where she
studied RNA translation dynamics during bacterial infection of mouse
macrophages. Her new postdoc project aims to identify the location of genetic
variants in cattle linked to important downstream phenotypes.


9:00 AM - 9:20 AM Registration / Posters on site
On site participants should report to The Roslin Institute reception area.
Online participants will be let in the meeting.

9:20 AM - 9:30 AM Welcome and Introduction

9:30 AM - 11:00 AM Session 1: Three talks by Helene Kiefer, Yanni Zeng and
Eveline Ibeaga-Awemu

11:00 AM - 11:30 AM Break and coffees / Posters on site

11:30 AM - 1:00 PM Session 2: Three talks by Peter Hansen, Konrad Rawlik and
Jessica Powell

1:00 PM - 2:00 PM Break for lunch / Posters on site

2:00 PM - 3:00 PM Lightening talks/Online poster discussion
To be determined closer to the date depending on submissions

Pau Navarro, PhD, SFHEA     My pronouns are she/her
MRC Human Genetics Unit, Institute of Genetics and Cancer, University of
**Responses to emails from me are only expected during your working hours**

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