For poster abstracts and more details, refer to https://pag.confex.com/pag/xxiii/webprogram/ on specific author names or the poster numbers.
By Luca Fontanesi
Summary: The relationships between genotype and metobotype and metabotype and phenotype were studied. Heritability varied between metabotypes. There were correlations between metabotype and phenotype. Candidate genes were identified that affect individual metabotypes.
By Tianfu Yang
Summary: Adaptive lasso and lasso-based permutation tests improve success rate but not true discovery rate.
By Haibo Liu
Summary: ESTs and mRNA from RNA-seq data were used to improve the annotation of the pig genome. UTR and isoform annotation was enhanced, and novel genes and polyA sites were discovered.
By Kwan-Suk Kim
Author Summary: Rectal temperature is correlated with heat stress in pigs, and selection for this trait can be used to develop pigs that are less susceptible to heat stress.
Summary: TALEN-mediated genome editing was used to generate α-Gal knockout and hDAF expressing transgenic pigs. These pigs can produce organs for xenotransplantation that may not undergo hyperacute rejection.
By Anoop Arya
Summary: As part of the FAANG project, miRNA editing is being studied, particularly A to I editing events, as these are the most common.
By Renata Veroneze
Summary: Using multiple populations for GBV estimation may or may not improve accuracy depending on the allelic frequencies in the validation set.
By Haja N. Kadarmideen
Summary: Genomic prediction with several methods have comparable accuracy to each other and phenotyping. There is a linear relationship between accuracy and number of SNPs in each group.
By Dongwon Seo
Summary: Three haplotypes were identified in the SLAI and SLAII regions, respectively, of Korean Yucatan miniature pigs. Together, there are six haplotypes: four heterozygous and two homozygous. Homozygous haplotypes can be bred for use in biomedical research.
By Hongyang Wang
Summary: Novel CNVs were discovered that were generated during domestication. Many were specific to Chinese or Western breeds due to the emphasis of different traits during selection.
By Luca Fontanesi
Summary: Twenty years of selection substantially modified the genome of the Italian Large White pig population, and allelic frequencies of four out of five SNPs studied showed evidence of selection in the direction favorable for production traits.
By Angela Canovas
Summary: Ninety-six genes and 30 splice variants were differentially expressed between pigs with extreme high and low fatness phenotypes. Lipid metabolism and fatty acid biosynthesis were enriched functions among these genes. Forty-two cis- and 50 trans- eQTL were identified.
By Jaemin Kim
Summary: Jeju black pigs (Korean native black pigs from Jeju Island) were analyzed for signatures of selection using XP-EHH, Tajima’s D, and MAF analysis. Many candidate genes under positive selection were identified.
By Mauricio Egidio Cantao
Summary: Gut microbiota differences were detected between pigs fed a diet with and pigs fed a diet without included antibiotics at 65 days of age, but not at five days of age.
By Richard Osei-Amponsah
Summary: ADFs are most closely related to European pigs, and signatures of selection were identified near genes affecting several various traits.
By Marcel Amills
Summary: In silico amino acid substitution prediction tools do not yield consistent predictions of the effects of missense polymorphisms.
By Pierre Mormede
Summary: Selection for a response in plasma cortisol levels to ACTH injection results in pigs with increased HPA axis activity, a trait that may improve performance in some reproductive, growth, and carcass traits.
By Claire Rogel-Gaillard
Summary: Gut microbiota composition was studied along with links to traits such as body weight and ADG. Looking at gut microbiota along with host genetics and zootechnical and health traits will provide insight into forces shaping animal performance.
By Woori Kwak
Summary: Methylation patterns were compared in small intestine and liver of fast and slow growing nursery pigs. Insulin receptor and axonal guidance signaling pathway were enriched in liver.
By Lucas L. Verardo
Summary: A GWAS was performed for number of teats using Bayesian methods, candidate genes were identified, and a candidate gene - transcription factor network was constructed. This increased understanding of gene interactions involved in number of teat determination.
By Melanie Trenhaile
Summary: Restricting energy intake during gilt development positively affects sow fertility. SNPs interacting with diet to influence age at puberty were identified, and candidate genes were located in these regions.
By Simone Guimaraes
Summary: A GWAS was performed for number of stillborn piglets using Bayesian methods, candidate genes were identified, and a candidate gene – transcription factor network was constructed. This increased understanding of gene interactions involved in number of stillborn piglets determination and was helpful in identifying the most probably candidate genes.
By Xinyun Li
Summary: miR 195 and 497 increase in longissimus muscle cells as pigs go through fetal development. Results indicate their function could be inhibiting myoblast proliferation through various proteins and genes, and their expression is negatively regulated by NF-Kb.
By Gary A. Rohrer
Summary: GWAS were done for number of ribs, lumbar vertebrae, and thoracolumbar vertebrae. Several regions with effects were found. Large effect regions changed number of ribs or lumbar vertebrae, and this caused a change in thoracolumbar vertebrae, with one exception on SSC18, which affected number of ribs and lumbar vertebrae without changing number of thoracolumbar vertebrae.
By Pengxia Niu
Summary: This study validated three markers previously identified as candidate genes for defense against PRRS. GBP1 genotype was associated with growth, viremia, and immune response, CD163 genotype was associated with growth and viremia, and MX1 genotype was associated with immune response for at least one time point.
By Igseo Choi
Author Summary: GWAS was done with pigs with cleared or persistent PRRSV infection. A large effect QTL was identified on SSC4 21 days post infection, confirming a previously identified QTL. Different genes play a role in viremia at 21 vs. 42 days post infection. The largest QTL identified was on SSC18 at 42 days post infection.
By Jun Heon Lee
Summary: The SLA nomenclature committee validates newly identified SLA sequences, assigns nomenclatures, and manages a SLA database. This is critical to swine immunology and health research, vaccine improvement, and the use of pigs as large animal models in transplantation studies.
By Emily Tosky
Author Summary: A QTL in the SLA II region was identified that is associated with PCV2b susceptibility. Associations between viremia and genotype and viremia and ADG have been confirmed in natural infections.
By Armand Sanchez
Author Summary: Variation was found in coding regions of toll-like receptors, and many made changes that could have functional consequences. This huge amount of variation could explain differences in immune response.
USA · USDA · NAGRP · Bioinformatics Coordination Program.