QTL #13862 Description:

 Trait Information
Trait name: Microphthalmia Vertebrate Trait Ontology: Eye morphology trait
Reported name: Product Trait Ontology: n/a
Symbol: MICROP Clinical Measurement Ontology: n/a
 QTL Map Information
QTL Peak Location:35.7 (cM)
QTL Span:34.5-36.9 (cM)
20.8-24.3 (Mbp)
Upper, "Suggestive":n/a
Upper, "Significant":D9M1722
Lower, "Significant":BMS332
Lower, "Suggestive":n/a
Analysis type:Association
Model tested:Mendelian
Test base:n/a
Threshold significance level:Significant
Dominance effect:n/a
Additive effect:n/a
Associated Gene:PITX3 (paired-like homeodomain 3)
Links:   NCBI GeneDB  |  Edit  |   Map view

 Extended information:

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  •  QTL Experiment in Brief
    Animals:Animals were Texel sheep.
     Breeds associated:
    Design:Animals were genotyped for approximately 50,000 SNPs across the genome, then for 3 microsatellite markers in a region of OAR 22, and analyzed for the presence of microphthalmia.
    Analysis:Two-point parametric linkage analysis was performed.
    Software:PLINK, Merlin
    Authors:Becker D, Tetens J, Brunner A, Bürstel D, Ganter M, Kijas J; International Sheep Genomics Consortium, Drögemüller C
    Affiliation:Institute of Genetics, Vetsuisse Faculty, University of Berne, Berne, Switzerland
    Title:Microphthalmia in Texel sheep is associated with a missense mutation in the paired-like homeodomain 3 (PITX3) gene
    Journal:PLoS One, 2010, 5(1): e8689
    Links:  PubMed  |  Abstract   |  List all QTL   |  Edit  
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