Release 56
(Apr 24, 2025)

Reference # 19828762 Details:

Authors:Moreno CR, Moazami-Goudarzi K, Briand S, Robert-Granié C, Weisbecker JL, Laurent P, Cribiu EP, Haley CS, Andréoletti O, Bishop S (Contact: Moreno@toulouse.inra.fr)
Affiliation:INRA, UR631, Amélioration Génétique des Animaux, BP52627, 31326 Castanet-Tolosan, France
Title:Mapping of QTL affecting classical scrapie incubation time in a population comprising several generations of scrapie infected sheep.
Journal:Journal of General Virology, 2010, 2):575-9 DOI: 10.1099/vir.0.014134-0
Abstract:

Although susceptibility to scrapie is largely controlled by the PrP gene, the role of other genes that affect scrapie resistance in sheep is now confirmed. Following the detection of quantitative trait loci (QTL) on chromosomes 6 and 18 in a half-sib family with an ARQ-VRQ susceptible PrP genotype, the whole pedigree of a naturally infected flock was investigated to confirm these QTL regions in different PrP genotypes. The present study has allowed us to confirm the QTL on the chromosome 18, and to demonstrate QTL effects in several PrP genotypes.

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