Release 56
(Apr 24, 2025)

Whole genome analysis for QTL/association enrichment

Version: Enrich S: beta v0.8
Search: to limit the list of your trait choices:
(optional) focus on chromosome with Mb windows across its length

Data:

Number of blood parameters traits:56
Number of QTL / associations found:841
Number of chromosomes where QTL / associations are found:30

Chi-squared (χ2) test: are blood parameters traits over-represented on some chromosomes?

Chromosomes Total χ2 df p-values FDR * Size of χ2
Chromosome X393.40056291.613466e-656.914854e-65
Chromosome 198.81816291.510838e-091.743275e-09
Chromosome 2128.91536291.472454e-141.840567e-14
Chromosome 32171.01752299e-411.588235e-40
Chromosome 410929.12464299e-411.588235e-40
Chromosome 5878.15672294.3159e-1661.294770e-164
Chromosome 6201.09600291.156095e-271.651564e-27
Chromosome 750.60888290.0077591328.026688e-03
Chromosome 896.95336292.988072e-093.201506e-09
Chromosome 9289.25792291.073101e-442.299502e-44
Chromosome 10451.46472292.525714e-771.262857e-76
Chromosome 1196.95336292.988072e-093.201506e-09
Chromosome 1298.81816291.510838e-091.743275e-09
Chromosome 13289.25792291.073101e-442.299502e-44
Chromosome 1422856.52544299e-411.588235e-40
Chromosome 15389.67152299.161637e-653.435614e-64
Chromosome 16339.33144291.221626e-543.664878e-54
Chromosome 17339.33144291.221626e-543.664878e-54
Chromosome 18243.17944291.065410e-351.682226e-35
Chromosome 1932.49680290.29849572.984957e-01
Chromosome 20289.25792291.073101e-442.299502e-44
Chromosome 21723.67400291.119723e-1331.679585e-132
Chromosome 22289.25792291.073101e-442.299502e-44
Chromosome 23128.91536291.472454e-141.840567e-14
Chromosome 24649.62912293.139182e-1183.139182e-117
Chromosome 25513.52448294.765817e-902.859490e-89
Chromosome 26243.17944291.065410e-351.682226e-35
Chromosome 27201.09600291.156095e-271.651564e-27
Chromosome 28513.52448294.765817e-902.859490e-89
Chromosome 29163.00816291.312508e-201.789784e-20

Chi-squared (χ2) test: Which of the 56 blood parameters traits are over-represented in the QTLdb

Traits Total χ2 df p-values FDR * Size of χ2
Adrenocorticotropic hormone level 188.64194 55 1.533191e-16 2.146467e-15
Alanine transaminase level 48.47056 55 0.720654 1.000000e+00
Alkaline phosphatase level 104.60889 55 6.28614e-05 2.707876e-04
Anti-Müllerian hormone level 138.2284 55 4.144451e-09 4.641785e-08
Aspartate aminotransferase level 48.47056 55 0.720654 1.000000e+00
Blood albumin level 55.45599 55 0.4574212 9.791944e-01
Blood beta-hydroxybutyrate level 59.43322 55 0.3173779 8.463411e-01
Blood calcium level 43.95596 55 0.8573203 1.000000e+00
Blood cortisol level 118.90144 55 1.328986e-06 7.442322e-06
Blood creatinine level 41.04997 55 0.918905 1.000000e+00
Blood glucose level 5.2296 55 1 1.000000e+00
Blood non-esterified fatty acid level 16.9867 55 0.9999998 1.000000e+00
Calcidiol level 242.95083 55 1.858598e-25 3.469383e-24
Cholesterol level 39.23507 55 0.946477 1.000000e+00
Cholinesterase level 57.12509 55 0.3960886 9.561776e-01
Creatine kinase level 23.02854 55 0.999956 1.000000e+00
Direct bilirubin level 21.68793 55 0.999984 1.000000e+00
Dopamine level 136.24487 55 7.682853e-09 6.146282e-08
Final packed red blood cell volume 55.06663 55 0.4721116 9.791944e-01
Gamma-glutamyl transferase level 48.47056 55 0.720654 1.000000e+00
Glutamate level 53.11536 55 0.5469607 1.000000e+00
Growth hormone level 34.04163 55 0.9882084 1.000000e+00
HDL cholesterol level 31.03929 55 0.9962409 1.000000e+00
Hematocrit 86.01369 55 0.004734131 1.656946e-02
Hemoglobin 56.27739 55 0.426865 9.561776e-01
Initial packed red blood cell volume 39.04881 55 0.9488646 1.000000e+00
Insulin level 38.51455 55 0.955284 1.000000e+00
Insulin-like growth factor 1 level 432.3736 55 5.265316e-60 2.948577e-58
LDL cholesterol level 114.92553 55 4.041553e-06 2.057518e-05
Lactate dehydrogenase level 39.04759 55 0.94888 1.000000e+00
Large unstained cell number 51.56247 55 0.6067618 1.000000e+00
Mean corpuscular hemoglobin concentration 69.39901 55 0.09160497 2.702833e-01
Mean corpuscular hemoglobin content 124.50259 55 2.648038e-07 1.647668e-06
Mean corpuscular volume 105.78833 55 4.644698e-05 2.167526e-04
Mean platelet volume 136.71202 55 6.646555e-09 6.146282e-08
Minimum packed red blood cell volume 56.57082 55 0.4161164 9.561776e-01
PCV variance 52.35867 55 0.5761732 1.000000e+00
PCVF minus PCVM 46.56615 55 0.7837411 1.000000e+00
PCVI minus PCVF 47.05834 55 0.7681147 1.000000e+00
PCVI minus PCVM 48.49693 55 0.7197342 1.000000e+00
Percentage decrease in PCV up to day 100 after challenge 32.59 55 0.9930218 1.000000e+00
Percentage decrease in PCV up to day 150 after challenge 47.79062 55 0.7439626 1.000000e+00
Platelet distribution width 80.89614 55 0.01308479 4.310284e-02
Platelet number 45.60225 55 0.8128064 1.000000e+00
Platelet-large cell ratio 56.40277 55 0.4222606 9.561776e-01
Prolactin level 10.45926 55 1 1.000000e+00
Red blood cell Na+/K+ ATPase activity 68.08334 55 0.1107061 3.099771e-01
Red blood cell distribution width 69.3917 55 0.09170327 2.702833e-01
Red blood cell number 128.33075 55 8.539884e-08 5.977919e-07
Red blood cell potassium level 34.04163 55 0.9882084 1.000000e+00
Serotonin level 312.15799 55 1.259589e-37 3.526849e-36
Serum chloride level 41.0179 55 0.9194626 1.000000e+00
Thyroxine level 17.05009 55 0.9999998 1.000000e+00
Total bilirubin level 97.60101 55 0.0003555680 1.327454e-03
Triglyceride level 100.12855 55 0.0001928799 7.715196e-04
Triiodothyronine level 21.22267 55 0.999989 1.000000e+00

Correlations found between some of these traits for your reference

No correlation data found on these traits

Overall Test

Data Chi'Square Test Fisher's Exact Test
Number of chrom.:30 χ2=44089.446240
Number of traits:56 df=1595
Number of QTLs:841 p-value=0

FOOT NOTE: * : FDR is short for "false discovery rate", representing the expected proportion of type I errors. A type I error is where you incorrectly reject the null hypothesis, i.e. you get a false positive. It's statistical definition is FDR = E(V/R | R > 0) P(R > 0), where V = Number of Type I errors (false positives); R = Number of rejected hypotheses. Benjamini–Hochberg procedure is a practical way to estimate FDR.

 

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