Release 56
(Apr 24, 2025)

Whole genome analysis for QTL/association enrichment

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Version: Enrich S: beta v0.8
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Data:

Number of milk composition - protein traits:37
Number of QTL / associations found:26,169
Number of chromosomes where QTL / associations are found:30

Chi-squared (χ2) test: are milk composition - protein traits over-represented on some chromosomes?

Chromosomes Total χ2 df p-values FDR * Size of χ2
Chromosome X22746.46521299e-419.310345e-41
Chromosome 1308.62699291.592042e-482.388063e-47
Chromosome 23099.04526299e-419.310345e-41
Chromosome 31089.94082298.143258e-2112.442977e-209
Chromosome 419573.07585299e-419.310345e-41
Chromosome 5149.15773294.100820e-184.100820e-18
Chromosome 62189541.23740299e-419.310345e-41
Chromosome 77564.46130299e-419.310345e-41
Chromosome 814780.23756299e-419.310345e-41
Chromosome 915082.22675299e-419.310345e-41
Chromosome 107245.47172299e-419.310345e-41
Chromosome 1143243.47287299e-419.310345e-41
Chromosome 1218774.60882299e-419.310345e-41
Chromosome 134057.84735299e-419.310345e-41
Chromosome 14340358.82566299e-419.310345e-41
Chromosome 153850.65068299e-419.310345e-41
Chromosome 163901.94082299e-419.310345e-41
Chromosome 1714234.52271299e-419.310345e-41
Chromosome 1817227.55668299e-419.310345e-41
Chromosome 1910280.05706299e-419.310345e-41
Chromosome 2094510.68656299e-419.310345e-41
Chromosome 2118270.08903299e-419.310345e-41
Chromosome 2216426.13742299e-419.310345e-41
Chromosome 233723.90977299e-419.310345e-41
Chromosome 2418214.45509299e-419.310345e-41
Chromosome 2517662.78509299e-419.310345e-41
Chromosome 2614087.47287299e-419.310345e-41
Chromosome 2727712.83831299e-419.310345e-41
Chromosome 2823942.12132299e-419.310345e-41
Chromosome 291893.80319299e-419.310345e-41

Chi-squared (χ2) test: Which of the 37 milk composition - protein traits are over-represented in the QTLdb

Traits Total χ2 df p-values FDR * Size of χ2
Milk alpha-S1-casein content 67.86578 36 0.001031775 1.908784e-03
Milk alpha-S1-casein percentage 155.21311 36 9.518274e-17 2.071624e-16
Milk alpha-S2-casein percentage 227.6786 36 1.085405e-29 3.089230e-29
Milk alpha-casein content 40.14524 36 0.2915427 3.595693e-01
Milk alpha-casein percentage 41.89762 36 0.2302572 2.937764e-01
Milk alpha-casein to beta-casein ratio 4.49596 36 1 1.000000e+00
Milk alpha-lactalbumin content 8.48403 36 0.9999994 1.000000e+00
Milk alpha-lactalbumin percentage 185.32608 36 5.371188e-22 1.242087e-21
Milk beta-casein content 12.54561 36 0.9999016 1.000000e+00
Milk beta-casein percentage 474.15623 36 7.807877e-78 1.444457e-76
Milk beta-lactoglobulin percentage 2286.43725 36 9e-41 2.775000e-40
Milk beta-lactoglobulin protein content 2374.49947 36 9e-41 2.775000e-40
Milk casein content 62.27717 36 0.004227546 6.800835e-03
Milk casein index 153.83674 36 1.631997e-16 3.354660e-16
Milk casein percentage 828.70021 36 1.028873e-150 3.806830e-149
Milk casein yield 62.83414 36 0.003691459 6.208363e-03
Milk delta-9-desaturase content 297.73904 36 6.10468e-43 5.646829e-42
Milk energy yield 60.37521 36 0.006658116 9.854012e-03
Milk glycosylated kappa-casein percentage 1998.9229 36 9e-41 2.775000e-40
Milk immunoglobulin G content 35.7542 36 0.4801886 5.731283e-01
Milk kappa-casein content 47.77022 36 0.09073227 1.198962e-01
Milk kappa-casein percentage 2810.37493 36 9e-41 2.775000e-40
Milk lactoferrin content 2280.87197 36 9e-41 2.775000e-40
Milk lactoperoxidase content 54.63894 36 0.02396222 3.410008e-02
Milk osteopontin content 4.49596 36 1 1.000000e+00
Milk phosphorylated alpha-S2-casein percentage 445.19205 36 5.233978e-72 6.455240e-71
Milk protein content 61.41537 36 0.00520254 8.020583e-03
Milk protein percentage 5435.69922 36 9e-41 2.775000e-40
Milk protein yield 2285.01035 36 9e-41 2.775000e-40
Milk protein yield persistency 49.60945 36 0.06505392 8.914796e-02
Milk protein-to-fat ratio 82.58155 36 1.605177e-05 3.125871e-05
Milk unglycosylated kappa-casein percentage 2089.96035 36 9e-41 2.775000e-40
Milk urea nitrogen content 202.16953 36 5.093153e-25 1.256311e-24
Milk urea nitrogen yield 225.68598 36 2.535372e-29 6.700626e-29
Milk whey protein content 64.52445 36 0.002429251 4.280109e-03
Milk whey protein percentage 22.10205 36 0.9665815 1.000000e+00
Milk whey protein yield 2.24798 36 1 1.000000e+00

Correlations found between some of these traits for your reference

No correlation data found on these traits

Overall Test

Data Chi'Square Test Fisher's Exact Test
Number of chrom.:30 χ2=2973553.727890
Number of traits:37 df=1044
Number of QTLs:26,169 p-value=0

FOOT NOTE: * : FDR is short for "false discovery rate", representing the expected proportion of type I errors. A type I error is where you incorrectly reject the null hypothesis, i.e. you get a false positive. It's statistical definition is FDR = E(V/R | R > 0) P(R > 0), where V = Number of Type I errors (false positives); R = Number of rejected hypotheses. Benjamini–Hochberg procedure is a practical way to estimate FDR.

 

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