From lvmillon ucdavis.edu Fri May 11 08:20:19 2012
Subject: Re: dog bp/cM conversion
From: "Lee V. Millon" <lvmillonucdavis.edu>
Postmaster: submission approved
To: Multiple Recipients of <angenmapanimalgenome.org>
Date: Fri, 11 May 2012 08:20:19 -0500
Hello Liz,
Perhaps this may help.
A comprehensive linkage map of the dog genome.
http://www.ncbi.nlm.nih.gov/pubmed/19966068
Wong AK, Ruhe AL, Dumont BL, Robertson KR, Guerrero G, Shull SM, Ziegle JS,
Millon LV, Broman KW, Payseur BA, *Neff MW*.
Genetics. 2010 Feb;184(2):595-605. Epub 2009 Dec 4.
http://www.ncbi.nlm.nih.gov/pubmed/19966068
http://www.genetics.org/content/184/2/595.long
Discussion:
..
"Despite the unique karyotypic features of the dog, the sex-averaged rate
of recombination across the genome (0.97 cM/Mb) is within the range of other
characterized mammals (0.5~1.1 cM/Mb). Genetic map-based estimates of
recombination rate are available for two additional carnivore species, house
cat (~1.1 cM/Mb; MENOTTI-RAYMOND et al. 1999) and silver fox (0.6 cM/Mb;
KUKEKOVA et al. 2007). While large differences in map quality and coverage
preclude detailed comparisons, the rate of recombination in dog is clearly not
an outlier among carnivores. Although fine-scale recombination rates evolve on
short evolutionary timescales (PTAK et al. 2005; WINCKLER et al. 2005),
the dog genetic map adds evidence for more rigid evolutionary constraints
on broader scale recombination rates (MYERS et al. 2005; DUMONT and PAYSEUR
2008)."
Lee
On Thu, May 10, 2012 at 1:01 PM, Liz Hare <doggeneearthlink.netwrote:
Hello,
I'm looking for references for conversion of bp to cM for the dog
genome. The rule of thumb for humans is 10^6 bp ~ 1 cM, but dogs have a
lot more LD, so the conversion would probably be different.
Thanks,
Liz
--
Liz Hare PhD
Dog Genetics LLC
doggeneearthlink.net
http://www.doggenetics.com
--
Lee V. Millon
Veterinary Genetics Lab
School of Veterinary Medicine
University of California
Davis, CA
95616
TEL: 530-752-1017
FAX: 530-752-3556
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