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One useful feature of
Gene Ontology (GO) is that it helps
to describe the basic term hierarchies and relationships between terms within the context
of biology. This GO Terms Classifications Counter helps users to analyze
batch GO term classifications by grouping and counting them against a given classification
methods such as GO-Slim. This tool is comprised with a set of perl CGI programs coupled
with a MySQL DBMS that stores the GO terms DAG data (with pre-computed terms associations).
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INTRODUCTION:
Batch analysis of GO annotations for gene function groups is a useful part of
high-throughput microarray or EST data analysis.
This utility is for users to count the occurrences of their GO terms within each
of the pre-defined set of parent/ancestor GO terms. The program takes
input of
GO terms (e.g. GO:0007067) in a list format or unformatted plain text file, perform
counts against one of the available classification methods
such as GO_slim, GOA, EGAD, MGI_GO_slim, GO-ROOT, etc. at user's choice, or against
one of your own classification methods, and then returns the results on the web
(if it takes too long, it will email the user with the results link).
The results include a table listing all counts and
percentages, along with a pie chart.
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USAGES: The use of the tool is as easy as following these three steps:
Step 1: Upload your GO id's
Step 2: Select a GO classification method
Step 3: Count occurrences of GO terms in each ancestral class
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QUESTIONS AND ANSWERS:
For proper use of this tool and related questions, see this list of
Frequently Asked Questions (FAQ). If you have any question
that's not covered by this FAQ, please don't hesitate to let us know.
All feedbacks on problems and suggestions to improve the tool are appreciated.
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PUBLICATIONS:
Zhi-Liang Hu, Jie Bao and James M. Reecy (2007).
"A Gene Ontology (GO) Terms Classifications Counter".
Plant & Animal Genome XV Conference, San Diego, CA, January 13-17, 2007.
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